The three most common prescription weight loss medications available—Mounjaro, Wegovy, and Saxenda—each have different mechanisms of action, dosing schedules, and ideal patient profiles. Many people ask, "Which one is better?" The truth is, the answer depends entirely on the individual. This article comprehensively breaks down their differences to help make your discussion with your doctor more efficient.
| Feature | Mounjaro | Wegovy | Saxenda |
|---|---|---|---|
| Mechanism | Dual GIP/GLP-1 | GLP-1 only | GLP-1 only |
| Frequency | Weekly | Weekly | Daily |
| Dose Range | 2.5–15 mg | 0.25–2.4 mg | 0.6–3.0 mg |
| Average Weight Loss | ★★★★★ ~20–22% |
★★★★ ~15–17% |
★★★ ~5–8% |
| Cost (Taiwan)/Mo | ~NT$8,000–15,000 | ~NT$6,000–12,000 | ~NT$3,000–6,000 |
| Nausea Risk | Moderate | Moderate | More Common |
| Diabetes Indication | ✅ Yes (Mounjaro) | ❌ No (Wegovy is a weight mgmt brand) | ❌ No (Saxenda is a weight mgmt brand) |
| NHI Coverage | Self-pay only | Self-pay only | Self-pay only |
* Costs vary by clinic and pharmacy and are references only. Weight loss effects are derived from their respective clinical trials. Side effect data come from separate trials and cannot be directly compared across medications.
Mounjaro is currently the most potent weight loss medication available. It targets both GIP and GLP-1 receptors, a dual mechanism that makes its weight loss significantly superior to single GLP-1 drugs. Clinical studies (SURMOUNT trials) show that users reaching the highest dose (15mg) lose an average of 20–22% of their body weight.
Wegovy is the flagship GLP-1 receptor agonist and the most widely used globally, backed by extensive clinical data. The STEP trials demonstrate an average weight loss of about 15–17%, showing significant and consistent results.
Saxenda was the earliest GLP-1 injection available for weight loss. It requires daily injections, costs relatively less, and has the most mature clinical safety data. Though its weight loss efficacy isn't as high as Mounjaro or Wegovy, it's still significant for many patients. It is currently self-pay in Taiwan.
Want to maximize weight loss results, have concurrent blood sugar issues, and are less sensitive to cost.
Prefer weekly injections, value cardiovascular protection, and seek a solid balance between cost and effect.
Have a limited budget, qualify for insurance coverage, and don't mind daily injections.
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